BCN Vitamin A 10000 U.I. Retinol

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Buy BCN Vitamin A 10000 U.I. Retinol Online

Vitamin A or retinol is a dermic anti-oxidant that nourishes and improves the skin appearance. Buy BCN Vitamin A Online

Vitamin A or Retinol works as an anti-oxidant for the skin, disarming free radicals that cause tissue and cell damage. It smoothes wrinkles and lines gradually, improves moisture and elasticity, diminishes sun damage and provides glow to the skin complexion. In addition, vitamin A increases the skin’s cell turnover, while also boosts collagen, resulting in a more youthful overall appearance. As well as working to diminish stretch marks, vitamin A assists the skin’s natural healing processes. This vitamin and its derivatives have displayed beneficial effects in controlling acne and in reversing skin damage caused by environmental factors.

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Vitamin A, in the retinoic acid form, plays an important role in gene transcription.

Once retinol has been taken up by a cell, it can be oxidized to retinal (retinaldehyde) by retinol dehydrogenases; retinaldehyde can then be oxidized to retinoic acid by retinaldehyde dehydrogenases.

The conversion of retinaldehyde to retinoic acid is an irreversible step; this means that the production of retinoic acid is tightly regulated, due to its activity as a ligand for nuclear receptors.

The physiological form of retinoic acid (all-trans-retinoic acid) regulates gene transcription by binding to nuclear receptors known as retinoic acid receptors (RARs) which are bound to DNA as heterodimers with retinoid “X” receptors (RXRs). RAR and RXR must dimerize before they can bind to the DNA.

RAR will form a heterodimer with RXR (RAR-RXR), but it does not readily form a homodimer (RAR-RAR). RXR, on the other hand, may form a homodimer (RXR-RXR) and will form heterodimers with many other nuclear receptors as well, including the thyroid hormone receptor (RXR-TR), the Vitamin D3 receptor (RXR-VDR), the peroxisome proliferator-activated receptor (RXR-PPAR) and the liver “X” receptor (RXR-LXR).[61]


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