For peri-menopausal women or in reproductive age suffering from dehydration of the vulva with or without irritations
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DESIRIAL® is the first antioxidant hyaluronic acid based gel specifically formulated to preserve women’s intimate health Buy Desirial Online.
Entirely dedicated to women’s intimate health, DESIRIAL® viscosupplement solution developed by Laboratoires VIVACY opens new treatment options in Gynecology and Intimate Plastic Surgery.
As many as 80% of women entering menopause are affected by vaginal dryness and about 50% of women completing menopause continue to experience vaginal dryness Buy Desirial Online.
Vaginal and/or vulvar dryness may affect women at any period of their lives, whether it is iatrogenic in origin (e.g. isotretinoin, tricyclic antidepressants, neuroleptics, etc.), or linked to menopause, particularly in the absence of Hormone Replacement Therapy (HRT).
During menopause, there is a decrease of estrogen secretion, which has an effect on fibroblasts, and leads to progressive hypotrophy of the dermis with flattening of the dermal-epidermal junction:
The vaginal mucosa becomes dry (the connective tissue has less vascularisation, is less hydrated and becomes thinner) just like the whole skin. The glandular cells getting less nutrition become atrophic and begin to function poorly.
The skin loses its elasticity. The collagen and elastin fibres degenerate and decrease, the fibroblasts become hypoactive and the Type III collagen increases to the detriment of the Type I collagen.
The degradation products of hyaluronan, the oligosaccharides and very low-molecular-weight hyaluronan, exhibit pro-angiogenic properties. In addition, recent studies showed hyaluronan fragments, not the native high-molecular weight molecule, can induce inflammatory responses in macrophages and dendritic cells in tissue injury and in skin transplant.
Note that, according to Canadian regulation, hyaluronan in HY-50 preparation should not be administered to animals to be slaughtered for horse meat. In Europe, however, the same preparation is not considered to have any such effect, and edibility of the horse meat is not affected.